The soluble form of Tylan® is mixed into drinking water for:

• Chickens
• Turkeys
• Swine

See below for more details on each. One jar contains 100 grams of Tylan® Soluble Powder and will make 400 gallons treated drinking water for swine and 50 gallons of treated water for poultry. Generally, a jar of Tylan® Soluble Powder will not expire until approximately 18 months after purchase. Tylan® is a registered trademark for Elanco's brand of Tylosin.

FEATURES / BENEFITS

Water soluble powder makes administration of this antibiotic easier for treating groups of animals.

Chickens: When chronic respiratory disease threatens birds and slows gain, strategic medication with Tylan® Soluble can help protect flock health and profitability. Tylan® Soluble is highly active against Mycoplasma.

• Quickly concentrates at the site of infection
• Can reduce the need to treat secondary infections
• Helps prevent production losses

By controlling Mycoplasma, Tylan® Soluble:

• Improves bird health
• Increases gain
• Improves feed efficiency
• Reduces mortality
• Reduces days-to-market

Turkeys: When chronic respiratory disease (CRD) threatens birds, strategic medication with Tylan® Soluble can help protect flock health and profitability. Tylan® Soluble is highly active against Mycoplasma gallisepticum and:

• Quickly concentrates at the site of infection
• Can reduce the need to treat secondary infections
• Helps prevent production losses

For difficulties with infectious sinusitis, Tylan® Soluble powder controls Mycoplasma to improve production efficiency:

• Improves bird health
• Maintains weight gain
• Maintains feed efficiency

Swine: Tylan® Soluble is approved for use in swine for the control and treatment of swine dysentery (bloody scours) caused by pathogens sensitive to tylosin.

SPECIFICATIONS

Slaughter withdrawal: Swine—48 hours; chickens—24 hours; turkeys—5 days

Store at or below 25°C (77°F).Excursions Permitted to 40°C (104°F).

Avoid Moisture.

Not for Human Use. Keep Out of Reach of Children.

Avoid contact with human skin. Exposure to tylosin may cause a rash.

INSTRUCTIONS

Chickens:

NE indication: 851 to 1,419 mg/gallon (225 to 375 ppm) in drinking water.

CRD indications: 2,000 mg/gallon (528 ppm) in drinking water.

Turkeys: 2,000 mg/gallon (528 ppm) in drinking water.

Swine: 250 mg/gallon (66 ppm) in drinking water.

Honey Bees: 200 mg/colony in confectioners/powdered sugar.

Mixing Directions for Medicated Drinking Water:

Always add the water to the powder. Do not pour the powder into the water. Prepare a fresh Tylan Soluble solution every three days. When mixing and handling tylosin, use protective clothing and impervious gloves. If using a water medicating pump see table below, otherwise mix as follows:

To assure thorough dissolution, first place the contents of one jar in a mixing container and add one gallon of water (3785 mL) to the powder to make a concentrated solution. To make medicated drinking water containing 250 mg/gallon (66 ppm), mix this concentrated solution with water to make 400 gallons (1514 liters) of medicated drinking water. To make medicated drinking water containing 851 to 1,419 mg/gallon (225 to 375 ppm), mix this concentrated solution with water to make from 117 gallons + 51 ounces (444 liters) to 70 gallons + 64 ounces (267 liters) of medicated drinking water, respectively. To make medicated drinking water containing 2,000 mg/gallon (528 ppm), mix this concentrated solution with water to make 50 gallons (189 liters) of medicated drinking water.

Mixing Directions for Water Medicating Pump (1:128 inclusion)*:

Desired Concentration in Drinking water        Jars of Tylan Soluble                 Volume of Water to Make Stock Solution

250 mg/gallon (66 ppm)                                             1                                                              3 gallons + 13 ounces

851 mg/gallon (225 ppm)                                           5                                                              4 gallons + 77 ounces

1,419 mg/gallon (375 ppm)                                        9                                                              5 gallons + 0 ounces

2,000 mg/gallon (528 ppm)                                       10                                                             3 gallons + 115 ounces

*This table applies only if the water medicating pump is set to deliver 1 ounce of stock solution per gallon of drinking water.

Mixing Directions for use in Honey Bees: Mix 200 mg tylosin in 20 g confectioners/powdered sugar. Use immediately.

Directions for Use

Chickens: NE indication: Administer medicated drinking water for a single five day period in broiler chickens. To assure all birds receive the intended medication, only medicated water should be available. These practices should be followed to assure both food safety and responsible antimicrobial drug use in chickens:

1) Use in flocks exhibiting signs of a necrotic enteritis outbreak, for example, increased mortality and lesions characteristic of necrotic enteritis upon necropsy;

2) Administer the full dose and dosing regimen once medication is initiated;

3) Use of Tylan Soluble or another macrolide is not advised if additional therapy is needed beyond the original course of medication.

CRD indications: Administer medicated drinking water for three days; however, medicated water may be administered for one to five days depending upon severity of infection. Treated chickens must consume enough medicated water to provide 50 mg per pound of body weight per day. Only medicated water should be available to the birds.

Turkeys: Administer medicated drinking water for three days; however, medicated water may be administered for two to five days depending upon severity of infection. Treated turkeys must consume enough medicated water to provide 60 mg per pound of body weight per day. Only medicated water should be available to the birds.

Swine: SD indication: Administer medicated drinking water for 3 to 10 days, depending upon severity of infection. Alternatively, administer medicated drinking water for 3 to 10 days, followed by 40 to 100 g tylosin per ton of complete feed (Type C medicated feed manufactured from Tylan Type A medicated article) for 2 to 6 weeks. Only medicated water should be available to swine while medicating with Tylan Soluble. PPE indication: Administer medicated drinking water for 3 to 10 days, followed by 40 to 100 g of tylosin per ton of complete feed (Type C medicated feed manufactured from Tylan A medicated article) for 2 to 6 weeks. Only medicated water should be available to swine while medicating with Tylan Soluble.

Honey Bee Colonies: Administer three treatments of medicated confectioners sugar once weekly for 3 weeks. The 200 mg dose is applied (dusted) over the top bars of the brood chamber.