Factrel 50ml - Rx
Zoetis - A cost-effective gonadotropin releasing hormone (GnRH) product that rapidly metabolizes without detectable levels in milk or tissues.
*Rx* Federal law restricts this drug to use by or on the order of a licensed veterinarian.
A cost-effective gonadotropin releasing hormone (GnRH) product that rapidly metabolizes without detectable levels in milk or tissues. It reduces the number of days until the next estrus in cattle treated with Factrel for ovarian cysts. The synthetic gonadorelin in Factrel is identical to the gonadorelin produced by the cow itself. Indicated for the treatment of ovarian follicular cysts in cattle.
Species: Beef and dairy heifers and cows
NADA 139-237, Approved by FDA
For the treatment of cystic ovaries in cattle.
FACTREL (gonadorelin hydrochloride) is a sterile solution containing 50 micrograms of synthetic gonadorelin (as hydrochloride) per mL in aqueous formulation containing 0.6% sodium chloride and 2% benzyl alcohol (as a preservative).
Gonadorelin is the gonadotropin releasing hormone (GnRH) which is produced by the hypothalamus and causes the release of the gonadotropin luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary.
FEATURES / BENEFITS
Treatment of ovarian cysts reduces the number of days until next estrus so you can get your animals bred back sooner.
There is no milk or slaughter withdrawals meaning no lost profit.
Lower cost per dose than some comparable products.
Because FACTREL is identical to endogenous GnRH such that both are rapidly metabolized without detectable levels in milk or tissue, no withdrawal period is required.
Not for use in humans.
Store at refrigerator temperature 2 to 8 °C (36 to 46 °F).
Women of childbearing age should handle with extreme caution.
MECHANISM OF ACTION
Follicular cysts are enlarged non-ovulatory follicles resulting from a malfunction of the neuroendocrine mechanism controlling follicular maturation and ovulation. Exogenous administration of agents possessing luteinizing hormone (LH) activity, such as pituitary extracts or human chorionic gonadotropin, often causes ovulation or regression of follicular cysts. FACTREL induces release of endogenous luteinizing hormone (LH) to produce this same effect.
No significant differences have been demonstrated in days from treatment to conception, frequency of cows conceiving at first or subsequent heats, or conception rates among treated or non-treated control animals.
FACTREL (gonadorelin hydrochloride) is indicated for the treatment of ovarian follicular cysts in cattle. The treatment effect of FACTREL when used in cattle with ovarian follicular cysts is a reduction in the number of days to first estrus.
The recommended dosage of FACTREL is 100 mcg/cow intramuscularly. Administer 2 ml intramuscularly; use as directed by your veterinarian.
SAFETY AND TOXICITY
In cows the intramuscular administration of up to 25 times recommended dosage (2,500 mcg/day) of FACTREL for 3 days did not affect any physiological or clinical parameter. Likewise, single intramuscular doses of 5 times recommended dosage (500 mcg) did not interfere with pregnancy. No evidence of irritation at injection site was found in any animal.