*Rx* Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Indicated in cattle, calves, horses, swine ,sheep, goats dogs and cats to counter hypoprothrombinemia ,induced by ingestion of coumarin-based compounds common ingredients in commercial rodenticides. Vitamin K1 Injection an aqueous colloidal solution of vitamin K1 for parenteral injection possesses the same type and degree of activity as does naturally occurring vitamin K. The primary function of vitamin K is to stimulate the production via the liver of active prothrombin from a precursor protein. The mechanism by which vitamin K promotes formation of prothrombin at the molecular level has not been established.
The action of the aqueous colloidal solution when administered intravenously is generally detectable within an hour or two and hemorrhage is usually controlled within 3 to 6 hours. A normal prothrombin level may often be obtained in 12 to 14 hours.

Injection
Vitamin K Injection
(Phytonadione)
Aqueous Colloidal Solution of Vitamin K1

DESCRIPTION:
Vitamin K1 Injection is a yellow sterile aqueous colloidal solution of vitamin K1 (phytonadione) available for injection by the intravenous intramuscular and subcutaneous routes. Each mL contains:

Inactive ingredients:

Added as a preservative:

ACTIONS:
Injection
Vitamin K Injection
(Phytonadione)
Aqueous Colloidal Solution of Vitamin K1

INDICATIONS:
Vitamin K1 Injection is indicated in cattle calves horses swine sheep goats dogs and cats to counter hypoprothrombinemia induced by ingestion of coumarin-based compounds common ingredients in commercial rodenticides. Vitamin K1 Injection is also indicated to counter hypoprothrombinemia caused by consumption of bishydroxycoumarin found in spoiled and moldy sweet clover.
NOTE: Regular determinations of prothrombin time response should be performed to guide in the initial and subsequent administration of Vitamin K1 Injection. The dosage should be adjusted accordingly.

CONTRAINDICATIONS:
Hypersensitivity to any component of this medication.

WARNINGS:
An immediate coagulant effect should not be expected after administration of phytonadione. A minimum of 1 to 2 hours is required for measurable improvement in the prothrombin time. Whole blood or component therapy may be necessary if the bleeding is severe.
Phytonadione will not counteract the anticoagulant action of heparin.
Repeated large doses of Vitamin K are not warranted in hepatic disease if the response to the initial therapy is unsatisfactory. Failure to respond to vitamin K may indicate that the condition being treated is inherently unresponsive to vitamin K.

PRECAUTIONS:
Protect from light at all times. Temporary resistance to prothrombin-depressing anticoagulants may result especially when larger doses of phytonadione are used.

ADVERSE REACTION:
Deaths have occurred following intravenous injection (See Box Warning at Beginning of Circular).
Pain swelling and tenderness at the injection site may occur. The possibility of allergic sensitivity including an anaphylactic reaction should be kept in mind.

DOSAGE AND ADMINISTRATION:
Cattle Calves Horses Swine Sheep and Goats:
Acute Hypoprothrombinemia (with Hemorrhage) - Intravenously 0.5 - 2.5 mg/kg body weight at a rate not to exceed 10 mg/minute in mature animals and 5 mg per minute in newborn and very young animals.
Non-acute hypoprothrombinemia-Intramuscularly or subcutaneously 0.5 - 2.5 mg/kg body weight.
Dogs and Cats:
Acute hypoprothrombinemia (with hemorrhage) - Intravenously 0.25-2.5 mg/kg body weight at a rate not to exceed 5mg/minute.
Non-Acute Hypoprothrombinemia-Intramuscularly or subcutaneously 0.25-2.5 mg/kg body weight.
Whenever possible Vitamin K1 Injection should be given by the intramuscular or subcutaneous routes. When intravenous injection is considered unavoidable the drug should be given very slowly at the rate indicated above. MONITOR PROTHROMBIN TIME AND ADJUST DOSAGE ACCORDINGLY.
Frequency and amount of subsequent doses should be guided by regular determination of prothrombin time response and clinical condition. If in 6 to 8 hours after parenteral administration the prothrombin time has not been shortened satisfactorily the dose should be repeated.
In the event of shock or excessive blood loss the use of whole blood or component therapy is indicated. THE SMALLEST EFFECTIVE DOSE SHOULD BE SOUGHT TO MINIMIZE THE RISK OF ADVERSE REACTION.

DIRECTIONS FOR DILUTION:
Vitamin K1 Injection may be diluted with 0.9% Sodium Chloride Injection 5% Dextrose Injection or 5% Dextrose w/ Sodium Chloride Injection. Other diluents should not be used. When dilutions are indicated administration should be started immediately after mixture with the diluent and unused portions of the dilution should be discarded.

Store in a cool place between 2° and 8°C (36°-48°F).
Not For Human Use
KEEP OUT OF REACH OF CHILDREN